POEMS Syndrome in a Patient with Castleman Disease: A Case Report

POEMS syndrome is a rare multisystem disorder that clinically manifests as paraneoplastic and monoclonal plasma cell dyscrasia. Its acronym derived from its principal characteristics: polyneuropathy, organomegaly, endocrinopathy, M proteins, skin changes. Here, case of was reported also having features Castleman disease. A 43-year-old man admitted with weakness all four limbs, tingling, heaviness, muscle cramps along headache for the last 6 months; examination revealed flaccid quadriparesis, generalized areflexia flexor plantar response, papilloedema, cervical lymphadenopathy, hepatomegaly, tender mass at left parieto-occipital region, pitting edema testicular atrophy. Laboratory tests thrombocytosis, high blood sugar, lytic lesions parietal bone, pelvis, intraosseous in Pareto-occipital region; nerve conduction study showed demyelinating motor neuropathy without block. Intraosseous biopsy solitary plasmacytoma immunohistochemical markers positive CD138 Ki- 67 MUM-1 lambda/kappa >10:1, suggesting dyscrasia lambda chain restriction. Biopsy lymph node With these clinical laboratory parameters, this finally diagnosed association disease which common accompaniment syndrome. J Bangladesh Coll Phys Surg 2022; 40: 204-208